Anti-Sucrase-Isomaltase [mglu1]
Invented by Prof Dallas Swallow from GEE UCL
Invented at University College London
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153495 |
| Applications | ELISA IP |
| Antigen/Gene or Protein Targets | Sucrase-isomaltase |
| Synonyms | Sucrase-isomaltase, CSID, Oligosaccharide alpha 1, 6 glucosidase, AKA: Mglu1 - [3G51/2E10] |
| Reactivity | Human |
| Relevance |
Sucrase-isomaltase is a glucosidase enzyme and type II transmembrane glycoprotein located in the apical brush border membrane of small intestinal enterocytes. Sucrase-isomaltase digests dietary sucrose, maltose and isomaltose, which produces monosaccharides which can be taken up into the enterocytes and ultimately used as a source of energy. Defects in sucrase-isomaltase are the cause of the disease; congenital sucrase-isomaltase deficiency also known as disaccharide intolerance I. This an autosomal recessive intestinal disorder that is clinically characterized by abdominal pain, fermentative diarrhea and cramping. |
| Host | Mouse |
| Immunogen | Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 supplemented with 20% Fetal calf Serum medium containing 10-6M thymidine, 1.6x10-7M hypoxanthine and 10-5M methotrexate. |
| Strain | Balb/c |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Immunology, Metabolism |
References: 2 entries
Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.
Expression of the ABH, Lewis, and related antigens on the glycoproteins of the human jejunal brush border.
Europe PMC ID: 3043765
Add a reference
References: 2 entries
Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.
Expression of the ABH, Lewis, and related antigens on the glycoproteins of the human jejunal brush border.
Add a reference
