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Anti-mglu1 [3G51/2E10]

Invented by Prof Dallas Swallow at GEE UCL

Info

Catalogue Number 153495
Applications ELISA IP
Antigen/Gene or Protein Targets Human sucrase-isomaltase
Synonyms Sucrase-isomaltase, CSID, Oligosaccharide alpha 1, 6 glucosidase
Reactivity Human
Relevance Sucrase-isomaltase is a glucosidase enzyme and type II transmembrane glycoprotein located in the apical brush border membrane of small intestinal enterocytes. Sucrase-isomaltase digests dietary sucrose, maltose and isomaltose, which produces monosaccharides which can be taken up into the enterocytes and ultimately used as a source of energy.

Defects in sucrase-isomaltase are the cause of the disease; congenital sucrase-isomaltase deficiency also known as disaccharide intolerance I. This an autosomal recessive intestinal disorder that is clinically characterized by abdominal pain, fermentative diarrhea and cramping.
Host Mouse
Immunogen Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 supplemented with 20% Fetal calf Serum medium containing 10-6M thymidine, 1.6x10-7M hypoxanthine and 10-5M methotrexate.
Strain Balb/c
Research Area Cancer, Cell Signaling & Signal Transduction, Immunology, Metabolism

References: 1 entry

Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.


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References: 1 entry

Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.


Add a reference

References: 1 entry

Green et al. 1988. Subcell Biochem. 12:119-53. PMID: 3043765.


Add a reference


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