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|Antigen/Gene or Protein Targets||Human sucrase-isomaltase|
|Synonyms||Sucrase-isomaltase, CSID, Oligosaccharide alpha 1, 6 glucosidase|
Sucrase-isomaltase is a glucosidase enzyme and type II transmembrane glycoprotein located in the apical brush border membrane of small intestinal enterocytes. Sucrase-isomaltase digests dietary sucrose, maltose and isomaltose, which produces monosaccharides which can be taken up into the enterocytes and ultimately used as a source of energy.
Defects in sucrase-isomaltase are the cause of the disease; congenital sucrase-isomaltase deficiency also known as disaccharide intolerance I. This an autosomal recessive intestinal disorder that is clinically characterized by abdominal pain, fermentative diarrhea and cramping.
|Immunogen||Normal human jejunal epithelial brush border-enriched membranes from a non-secretor and blood group O|
|Recommended Growing Conditions||RPMI 1640 supplemented with 20% Fetal calf Serum medium containing 10-6M thymidine, 1.6x10-7M hypoxanthine and 10-5M methotrexate.|
|Research Area||Cancer, Cell Signaling & Signal Transduction, Immunology, Metabolism|
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