| Catalogue Number | 153414 |
| Antigen/Gene or Protein Targets | Abcc2 gene |
| Synonyms | Multidrug resistance-associated protein 2, MRP2, cMOAT, ABCC2 |
| Model | Conditional KO |
| Relevance | Multidrug resistance associated protein 2 is a member of the super family of ATP-binding cassette (ABC) transporters. These proteins are involved in transport of various molecules across extra and intracellular membranes. |
| Production Details | The model was created by targeting the Abcc2 gene in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations. |
| Conditional | Yes |
| Growth/Phenotype Keywords | Albino |
| Mouse Genetic Background/Cross History | FVB Background |
| Zygosity |
The colony is maintained by mating homozygotes. Wild type for Nnt mutation; carries Pde6brd1 mutation |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Drug Discovery & Development |
| Notes |
This strain encodes a disruption of the Abcc2 gene which codes for multidrug resistance protein 2. Useful for the examination of compound uptake and elimination mechanisms as well as studies on drug resistance in tumors. The Mrp2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. |
van Waterschoot et al. 2010. Br J Pharmacol. 160(5):1224-33. PMID: 20590614.
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
Europe PMC ID: 20590614
Vlaming et al. 2006. J Pharmacol Exp Ther. 318(1):319-27. PMID: 16611851.
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
Europe PMC ID: 16611851
van Waterschoot et al. 2010. Br J Pharmacol. 160(5):1224-33. PMID: 20590614.
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
Vlaming et al. 2006. J Pharmacol Exp Ther. 318(1):319-27. PMID: 16611851.
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
