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Anti-KSR [MINT/1/14]

Info

Catalogue Number 153392
Applications IHC WB
Antigen/Gene or Protein Targets KSR
Synonyms RSU2; KSR
Reactivity Human, Mouse and Rat
Relevance Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. In unstimulated cells, where the phosphorylated form is bound to a 14-3- 3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
Host Rat
Immunogen Recombinant human KSR protein
Subclass IgG2a
Molecular Weight (kDa) 140
Research Area Cancer, Cell Signaling & Signal Transduction

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