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Anti-Factor VIII:c heavy chain [RFF-VIII:c/10]

Invented by Prof Alison Goodall at University Of Leicester

Info

Catalogue Number 153203
Applications IF WB
Antigen/Gene or Protein Targets Factor VIII:c heavy chain
Reactivity Human
Relevance The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa.
Host Mouse
Immunogen Purified human factor VIII
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
Research Area Cardiovascular

References

There are 6 reference entries for this reagent.

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References: 6 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.

Europe PMC ID: 3937279

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

WB

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.

Europe PMC ID: 2413885

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

Monoclonal antibodies to human procoagulant factor VIII.

Europe PMC ID: 6403638


Add a reference

References: 6 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

WB

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

Monoclonal antibodies to human procoagulant factor VIII.


Add a reference

Inventor Information