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Anti-PITX3, Polyclonal [PITX3]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets PITX3
Reactivity Human and Mouse
Relevance Transcriptional regulator which is important for the differentiation and maintenance of meso­diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long­term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1­mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell­specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Molecular Weight (kDa) 31.8   
Research Area Epigenetics & Nuclear Signalling, Neurobiology

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