Anti-RUNX3 [K12P3F11*C9]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Info
![Image thumbnail for Anti-RUNX3 [K12P3F11*C9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/a70fbe3d-b61b-43f0-a97c-c1eda8116782.png)
| Catalogue Number | 152611 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Runt-related transcription factor 3 |
| Reactivity | Human |
| Relevance | Runx3 (also known as AML2 and CBF alpha 3) forms a heterodimer with a beta subunit. The complex binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Host | Mouse |
| Immunogen | Peptide – QFDRSFPTL |
| Positive Control | WB - Jurkat cell lysates; IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 44 |
| Myeloma Used | P3X63Ag8.653 |
| Research Area | Epigenetics & Nuclear Signalling |
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