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Anti-FIKK4.2 [127]

Info

Applications N/A
Antigen/Gene or Protein Targets FIKK4.2
Reactivity Plasmodium
Relevance Monoclonal antibody to the R45 antigen, now known as FIKK4.2 and putative exported kinase of Plasmodium falciparum. A unique family of parasite putative exported kinases, collectively called FIKK (Phenylalanine (F) – Isoleucine (I) – Lysine (K) – Lysine (K)), has recently been implicated in the adhesive and mechanical properties of red blood cells caused by infection with the malaria parasite Plasmodium falciparum. FIKK4.2, one member of the FIKK family, can function as an active kinase and is localised in a novel and distinct compartment of the parasite-infected red blood cell; disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasite’s ability to modify and remodel the red blood cells in which it multiplies.
Host Mouse
Subclass IgG1 kappa
Notes UK Biosafety level: 1
Research Area Adhesion, Cardiovascular, Parasitology

References: 1 entry

Kats et al. 2014. Int J Parasitol. 44(5):319-28. PMID: 24530877.


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References: 1 entry

Kats et al. 2014. Int J Parasitol. 44(5):319-28. PMID: 24530877.


Add a reference

References: 1 entry

Kats et al. 2014. Int J Parasitol. 44(5):319-28. PMID: 24530877.


Add a reference


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