Anti-CD49e [SNAKA52]
Invented at University of Manchester
- Datasheet
- References (6)
- Inventor Info
Info
Catalogue Number | 152486 |
Applications | ELISA Fn |
Antigen/Gene or Protein Targets | Integrin alpha5 (CD49e) |
Synonyms | Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A |
Reactivity | Human |
Relevance | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
Host | Mouse |
Immunogen | α5β1 purified from human placenta. |
Positive Control | HeLa cells |
Subclass | IgG |
Myeloma Used | P3X63Ag8.653 |
Notes | The binding of SNAKA52 is inhibited by anti-beta1 mAbs, indicating that its epitope is close to the interface between the alpha and beta subunits. |
Research Area | Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology |
References: 6 entries
Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Europe PMC ID: 15615773
Mould et al. 2003. J Biol Chem. 278(19):17028-35. PMID: 12615914.
Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement.
Europe PMC ID: 12615914
Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.
Europe PMC ID: 10567237
Burrows et al. 1999. Biochem J. 344 Pt 2:527-33. PMID: 10567237.
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References: 6 entries
Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Mould et al. 2003. J Biol Chem. 278(19):17028-35. PMID: 12615914.
Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement.
Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.
Burrows et al. 1999. Biochem J. 344 Pt 2:527-33. PMID: 10567237.
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Add a reference