Anti-CD49b [31H4]
Invented at University of Manchester
- Datasheet
- References (16)
- Inventor Info
Info
| Catalogue Number | 152485 |
| Applications | ELISA FACS IP |
| Antigen/Gene or Protein Targets | Integrin alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| Synonyms | Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor; Alpha-2 Subunit; Human Platelet Alloantigen System; Platelet Glycoprotein GPIa; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR |
| Reactivity | Human |
| Relevance | CD49b also known as integrin alpha-2, VLA-2 subunit alpha or collogen receptor. CD49b is a 1181 amino acid ¦130 kDa single pass type-1 transmembrane glycoprotein which forms a heterodimer with integrin beta-1 and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. |
| Host | Mouse |
| Immunogen | Purified human b1 integrin preparation from HT1080 fibrosarcoma cell extract. |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Notes |
Does not cross-react with Rat. Mouse anti Human CD49b antibody, clone 31H4 has been identified as being capable of immunoprecipitating the integrin a2 subunit from human cell-lines surface labelled with 125I. It has been confirmed specific to a2 by relative expression of antigen on various cell lines by flow cytometry, and recognition of affinity purified a2b1 in dot blots. |
| Research Area | Adhesion, Cell Signaling & Signal Transduction, Immunology |
References: 16 entries
Tanaka et al. 2012. Int J Oncol. 41(5):1837-44. PMID: 22923148.
Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells.
Europe PMC ID: 22923148
Tanaka et al. 2012. Oncol Rep. 28(1):330-6. PMID: 22552543.
Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells.
Europe PMC ID: 22552543
Tanaka et al. 2010. Int J Oncol. 37(1):125-31. PMID: 20514404.
Establishment and characterization of novel human uterine leiomyosarcoma cell lines.
Europe PMC ID: 20514404
Tanaka et al. 2009. Int J Mol Med. 23(2):173-80. PMID: 19148540.
Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen.
Europe PMC ID: 19148540
Tanaka et al. 2008. Int J Mol Med. 22(5):581-7. PMID: 18949377.
Autocrine/paracrine regulation of human endometrial stromal remodeling by laminin and type IV collagen.
Europe PMC ID: 18949377
Tanaka et al. 2008. Oncol Rep. 20(1):13-23. PMID: 18575713.
Experimental characterization of recurrent ovarian immature teratoma cells after optimal surgery.
Europe PMC ID: 18575713
Tanaka et al. 2006. Oncol Rep. 15(4):939-47. PMID: 16525683.
Optimal combination chemotherapy and chemoradiotherapy with etoposide for advanced cervical squamous cancer cells in vitro.
Europe PMC ID: 16525683
Tanaka et al. 2005. Oncol Rep. 14(4):941-8. PMID: 16142355.
Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells.
Europe PMC ID: 16142355
Add a reference
References: 16 entries
Tanaka et al. 2012. Int J Oncol. 41(5):1837-44. PMID: 22923148.
Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells.
Tanaka et al. 2012. Oncol Rep. 28(1):330-6. PMID: 22552543.
Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells.
Tanaka et al. 2010. Int J Oncol. 37(1):125-31. PMID: 20514404.
Establishment and characterization of novel human uterine leiomyosarcoma cell lines.
Tanaka et al. 2009. Int J Mol Med. 23(2):173-80. PMID: 19148540.
Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen.
Tanaka et al. 2008. Int J Mol Med. 22(5):581-7. PMID: 18949377.
Autocrine/paracrine regulation of human endometrial stromal remodeling by laminin and type IV collagen.
Tanaka et al. 2008. Oncol Rep. 20(1):13-23. PMID: 18575713.
Experimental characterization of recurrent ovarian immature teratoma cells after optimal surgery.
Tanaka et al. 2006. Oncol Rep. 15(4):939-47. PMID: 16525683.
Optimal combination chemotherapy and chemoradiotherapy with etoposide for advanced cervical squamous cancer cells in vitro.
Tanaka et al. 2005. Oncol Rep. 14(4):941-8. PMID: 16142355.
Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells.
Add a reference
