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Anti-p27 [SX53G8.5]

Info

Applications IHC WB
Antigen/Gene or Protein Targets p27
Synonyms Cyclin-Dependent Kinase Inhibitor 1B; P27KIP1; KIP1; Cyclin-Dependent Kinase Inhibitor P27; CDKN4; MEN1B; MEN4
Reactivity Human
Relevance p27 (cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27, Kip27) is a 27kD cyclin-dependent inhibitor. p27 is localized in the nucleus and cytoplasm (phospho-specific). This protein functions in G1 arrest and binds and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2. p27Kip1 mediates TGF β-induced G1 arrest and regulates cell motility. This kinase has also been implicated in translational control. Akt phosphorylation causes p27 Kip1 export to cytoplasm; p27 Kip1 has also been shown to be ubiquitinated. p27 Kip1 has been shown to interact with NUP50, Skp2, and PKB/Akt.
Host Mouse
Subclass IgG1 kappa
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 1 entry

Fredersdorf et al. 1997. Proc Natl Acad Sci U S A. 94(12):6380-5. PMID: 9177226.


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References: 1 entry

Fredersdorf et al. 1997. Proc Natl Acad Sci U S A. 94(12):6380-5. PMID: 9177226.


Add a reference

References: 1 entry

Fredersdorf et al. 1997. Proc Natl Acad Sci U S A. 94(12):6380-5. PMID: 9177226.


Add a reference


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