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Anti-ERCC5 [1XPG-1B5]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  XPG (Xeroderma pigmentosum group G) 
Reactivity N/A
Relevance ERCC5 or XPG is a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome.
Host Mouse
Immunogen KKRRKLRRARGRKRKT
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

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