Anti-MMP11 [5ST-4A9]
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Info
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | MMP11 / Stromelysin-3 |
| Reactivity | Human |
| Relevance | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, MMP11 cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. |
| Host | Mouse |
| Immunogen | Recomb prot |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit |
| Research Area | Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
References: 4 entries
Luo et al. 1999. J Biol Chem. 274(52):37177-85. PMID: 10601280.
Transcriptional induction of stromelysin-3 in mesodermal cells is mediated by an upstream CCAAT/enhancer-binding protein element associated with a DNase I-hypersensitive site.
Europe PMC ID: 10601280
Schönbeck et al. 1999. J Exp Med. 189(5):843-53. PMID: 10049948.
Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo.
Europe PMC ID: 10049948
Add a reference
References: 4 entries
Luo et al. 1999. J Biol Chem. 274(52):37177-85. PMID: 10601280.
Transcriptional induction of stromelysin-3 in mesodermal cells is mediated by an upstream CCAAT/enhancer-binding protein element associated with a DNase I-hypersensitive site.
Europe PMC ID: 10601280
Schönbeck et al. 1999. J Exp Med. 189(5):843-53. PMID: 10049948.
Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo.
Europe PMC ID: 10049948
Add a reference
References: 4 entries
Luo et al. 1999. J Biol Chem. 274(52):37177-85. PMID: 10601280.
Transcriptional induction of stromelysin-3 in mesodermal cells is mediated by an upstream CCAAT/enhancer-binding protein element associated with a DNase I-hypersensitive site.
Schönbeck et al. 1999. J Exp Med. 189(5):843-53. PMID: 10049948.
Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo.
Add a reference
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