Anti-Cytochrome P450 26A1 [F27P6A1]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
- References (8)
- Inventor Info
Info
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections. Images are showing strong cytoplamic positivity of CYP26A1 in primary colorectal cancer using the Anti-CYP26A1 [F27P6A1]. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/b54220d3-4688-4ddc-82f1-7aa9eca25317.png)
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections. Images are showing strong cytoplamic positivity of CYP26A1 in primary colorectal cancer using the Anti-CYP26A1 [F27P6A1]. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/b54220d3-4688-4ddc-82f1-7aa9eca25317.png)
![Image thumbnail for Anti-Cytochrome P450 26A1 [F27P6A1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/60d942ad-0613-4380-b53a-4656754dabed.jpg)
![Image thumbnail for Anti-Cytochrome P450 26A1 [F27P6A1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/59a0639e-59dd-471c-8901-251b5636925e.jpg)
![Image thumbnail for Anti-Cytochrome P450 26A1 [F27P6A1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/933f1c81-5c98-4872-b30b-002469aabda0.jpg)
![Image thumbnail for Anti-Cytochrome P450 26A1 [F27P6A1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ffe8170b-b520-468f-815e-221db6010a02.jpg)
![Image thumbnail for Anti-Cytochrome P450 26A1 [F27P6A1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/b54220d3-4688-4ddc-82f1-7aa9eca25317.png)
| Catalogue Number | 152114 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | CYP26A1 Cytochrome P450 26A1 (Retinoic acid-metabolizing cytochrome) (P450 retinoicacid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). |
| Reactivity | Human |
| Relevance | Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide PARFTHFHGE (C-terminal sequence) |
| Positive Control | IHC: formalin-fixed, paraffin-embedded liposarcoma sections. WB: over expression lysates |
| Subclass | IgG2b kappa |
| Molecular Weight (kDa) | 18.4 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM plus 60 ml Fetal Bovine Serum plus 3ml L-Glutamine). |
| Strain | Balb/c |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References: 8 entries
Stoney et al. 2015. Brain Struct Funct. :. PMID: 26374207.
Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.
Europe PMC ID: 26374207
Brown et al. 2014. PLoS One. 9(3):e90776. PMID: 24608339.
The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer.
Europe PMC ID: 24608339
Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Europe PMC ID: 16243809
Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Europe PMC ID: 15897573
Add a reference
References: 8 entries
Stoney et al. 2015. Brain Struct Funct. :. PMID: 26374207.
Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.
Brown et al. 2014. PLoS One. 9(3):e90776. PMID: 24608339.
The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer.
Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Add a reference
