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Anti-Factor VIII:c light chain [RFF-VIII:c/5]


Catalogue Number 151531
Applications IF WB
Antigen/Gene or Protein Targets Factor VIII:c light chain
Reactivity Human
Relevance The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody may be used for the purification of Factor VIII from normal plasma and cryoprecipitate.
Host Mouse
Immunogen Purified Human FVIII
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
Research Area Cardiovascular

References: 3 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

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