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Anti-Factor VIII:c light chain [RFF-VIII:c/5]

Invented by Prof Alison Goodall at University of Leicester

Info

Catalogue Number 151531
Applications IF WB
Antigen/Gene or Protein Targets Factor VIII:c light chain
Reactivity Human
Relevance The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody may be used for the purification of Factor VIII from normal plasma and cryoprecipitate.
Host Mouse
Immunogen Purified Human FVIII
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
Research Area Cardiovascular

References: 6 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.

Europe PMC ID: 3937279

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.

Europe PMC ID: 2413885

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

Monoclonal antibodies to human procoagulant factor VIII.

Europe PMC ID: 6403638


Add a reference

References: 6 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.

Europe PMC ID: 3937279

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.

Europe PMC ID: 2413885

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

Monoclonal antibodies to human procoagulant factor VIII.

Europe PMC ID: 6403638


Add a reference

References: 6 entries

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

Monoclonal antibodies to human procoagulant factor VIII.


Add a reference


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