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Anti-Factor VIII [RFF-VIII:c/8]


Catalogue Number 151529
Applications IF Fn WB
Antigen/Gene or Protein Targets Factor VIII
Reactivity Human
Relevance The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
Host Mouse
Immunogen Purified human factor VIII
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
Research Area Cardiovascular

References: 5 entries

Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.

Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.

Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.

Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.

Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.

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