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Anti-BCL2 [bcl-2/100]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151406
Applications IHC WB
Antigen/Gene or Protein Targets Bcl2
Reactivity Human
Relevance The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.
Host Mouse
Immunogen Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 13 entries

Soilu-Hänninen et al. 1999. J Neurosci. 19(12):4828-38. PMID: 10366617.

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.


Add a reference

References: 13 entries

Soilu-Hänninen et al. 1999. J Neurosci. 19(12):4828-38. PMID: 10366617.

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.


Add a reference

References: 13 entries

Soilu-Hänninen et al. 1999. J Neurosci. 19(12):4828-38. PMID: 10366617.

Navratil et al. 1995. J Clin Pathol. 48(1):18-21. PMID: 7706514.

Ashton-Key et al. 1995. Histopathology. 26(1):75-8. PMID: 7713486.

Piris et al. 1994. Br J Cancer. 69(2):337-41. PMID: 8297731.

Leek et al. 1994. Br J Cancer. 69(1):135-9. PMID: 8286195.

de Jong et al. 1994. Cancer Res. 54(1):256-60. PMID: 8261449.

Pezzella et al. 1993. N Engl J Med. 329(10):690-4. PMID: 8393963.

Doussis et al. 1993. Am J Clin Pathol. 99(6):663-7. PMID: 8322700.

Pezzella et al. 1993. Histopathology. 22(1):39-44. PMID: 8436340.

Gaulard et al. 1992. Am J Pathol. 140(5):1089-95. PMID: 1374590.

Pezzella et al. 1992. Br J Cancer. 65(1):87-9. PMID: 1733447.

Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 1979117.

Lehmkuhl et al. 1977. Am J Vet Res. 38(11):1717-20. PMID: 201196.


Add a reference


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