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Anti-BCL2 [bcl-2/100]


Catalogue Number 151406
Applications IHC WB
Antigen/Gene or Protein Targets Bcl2
Reactivity Human
Relevance The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.
Host Mouse
Immunogen Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 13 entries

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