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Anti-CD79b [B29/123]


Catalogue Number 151376
Applications IHC WB
Antigen/Gene or Protein Targets CD79b
Synonyms CD79b Molecule; CD79B Antigen (Immunoglobulin-Associated Beta); Immunoglobulin-Associated B29 Protein; B-Cell-Specific Glycoprotein B29; Ig-Beta
Reactivity Human
Relevance The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling.
Host Mouse
Immunogen Synthetic peptide representing the c-terminus from residue 215 of the murine B29 polypeptide.
Subclass IgG2b
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Cell Signaling & Signal Transduction, Immunology

References: 6 entries

Hauser et al. 2013. Mol Immunol. 54(3-4):247-53. PMID: 23318223.

Ouchida et al. 2010. J Immunol. 185(1):294-301. PMID: 20519653.

Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.

Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.

Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.

Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.

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