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Anti-CD68 [Y1/82A]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151370
Applications FACS IHC IF WB
Antigen/Gene or Protein Targets CD68
Synonyms CD68 Molecule; CD68 Antigen; Macrophage Antigen CD68; GP110; Scavenger Receptor Class D; Member; Scavenger Receptor Class D; SCARD1; LAMP4
Reactivity Human
Relevance CD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.
Host Mouse
Immunogen Lysosomal contents of lung macrophages
Subclass IgG2a
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Cell Type or Organelle Marker, Immunology, Stem Cell Biology

References: 14 entries

MacParland et al. 2017. ACS Nano. :. PMID: 28040885.

FACS

Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

Europe PMC ID: 28040885

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

IF

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Europe PMC ID: 26178906

Cañete et al. 2015. Arthritis Res Ther. 17:173. PMID: 26156866.

IF

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis.

Europe PMC ID: 26156866

Doussis et al. 1993. J Clin Pathol. 46(4):334-6. PMID: 7684403.

CD68 reactivity of non-macrophage derived tumours in cytological specimens.

Europe PMC ID: 7684403

Pulford et al. 1990. Int Immunol. 2(10):973-80. PMID: 2078523.

Distribution of the CD68 macrophage/myeloid associated antigen.

Europe PMC ID: 2078523

Micklem et al. 1989. Br J Haematol. 73(1):6-11. PMID: 2803980.

A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.

Europe PMC ID: 2803980

Pulford et al. 1989. J Clin Pathol. 42(4):414-21. PMID: 2654191.

KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections.

Europe PMC ID: 2654191


Add a reference

References: 14 entries

MacParland et al. 2017. ACS Nano. :. PMID: 28040885.

FACS

Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

Europe PMC ID: 28040885

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

IF

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Europe PMC ID: 26178906

Cañete et al. 2015. Arthritis Res Ther. 17:173. PMID: 26156866.

IF

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis.

Europe PMC ID: 26156866

Doussis et al. 1993. J Clin Pathol. 46(4):334-6. PMID: 7684403.

CD68 reactivity of non-macrophage derived tumours in cytological specimens.

Europe PMC ID: 7684403

Pulford et al. 1990. Int Immunol. 2(10):973-80. PMID: 2078523.

Distribution of the CD68 macrophage/myeloid associated antigen.

Europe PMC ID: 2078523

Micklem et al. 1989. Br J Haematol. 73(1):6-11. PMID: 2803980.

A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.

Europe PMC ID: 2803980

Pulford et al. 1989. J Clin Pathol. 42(4):414-21. PMID: 2654191.

KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections.

Europe PMC ID: 2654191


Add a reference

References: 14 entries

MacParland et al. 2017. ACS Nano. :. PMID: 28040885.

FACS

Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

Conrad et al. 2015. Arthritis Res Ther. 17:179. PMID: 26178906.

IF

In vivo pre-activation of monocytes in patients with axial spondyloarthritis.

Cañete et al. 2015. Arthritis Res Ther. 17:173. PMID: 26156866.

IF

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis.

Doussis et al. 1993. J Clin Pathol. 46(4):334-6. PMID: 7684403.

CD68 reactivity of non-macrophage derived tumours in cytological specimens.

Pulford et al. 1990. Int Immunol. 2(10):973-80. PMID: 2078523.

Distribution of the CD68 macrophage/myeloid associated antigen.

Micklem et al. 1989. Br J Haematol. 73(1):6-11. PMID: 2803980.

A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.

Pulford et al. 1989. J Clin Pathol. 42(4):414-21. PMID: 2654191.

KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections.


Add a reference


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