Anti-ASF1 [ASF 4A1/3]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151319 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Anti-Silencing Function 1 (ASF1) |
| Reactivity | Human and Mouse |
| Relevance | Anti-silencing function 1 (Asf1) belongs to the H3/H4 family of histone chaperones. Its function has not been fully elucidated but it is believed to be involved in ensuring a constant supply of histones at sites of nucleosome assembly. Asf1 interacts with the DNA damage checkpoint protein Rad53 and so may have a role in cell cycle regulation and DNA responses. ASF1 A and B (the two human subtypes) are the only known substrate for Tousled-like kinase (TLK). The Tousled kinases are themselves regulated by the checkpoint protein kinases involved in the DNA damage response. |
| Host | Mouse |
| Immunogen | FLAG-ASF1A |
| Subclass | IgG2a |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | ASF 4A1/3 detects both ASF1A and ASF1B. |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 2 entries
Silljé et al. 2001. Curr Biol. 11(13):1068-73. PMID: 11470414.
Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.
Europe PMC ID: 11470414
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References: 2 entries
Silljé et al. 2001. Curr Biol. 11(13):1068-73. PMID: 11470414.
Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.
Add a reference
