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Anti-ASF1 [ASF 4A1/3]


Catalogue Number 151319
Applications WB
Antigen/Gene or Protein Targets Anti-Silencing Function 1 (ASF1)
Reactivity Human and Mouse
Relevance Anti-silencing function 1 (Asf1) belongs to the H3/H4 family of histone chaperones. Its function has not been fully elucidated but it is believed to be involved in ensuring a constant supply of histones at sites of nucleosome assembly. Asf1 interacts with the DNA damage checkpoint protein Rad53 and so may have a role in cell cycle regulation and DNA responses. ASF1 A and B (the two human subtypes) are the only known substrate for Tousled-like kinase (TLK). The Tousled kinases are themselves regulated by the checkpoint protein kinases involved in the DNA damage response.
Host Mouse
Immunogen FLAG-ASF1A
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes ASF 4A1/3 detects both ASF1A and ASF1B.
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 1 entry

Silljé et al. 2001. Curr Biol. 11(13):1068-73. PMID: 11470414.

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