Anti-XRCC2 [XRCC2 7B7/3]
Invented by Dr Stephen West from Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (5)
- Inventor Info
Info
| Catalogue Number | 151273 |
| Applications | WB |
| Antigen/Gene or Protein Targets | XRay Repair Cross Complementing 2 (XRCC2) |
| Reactivity | Human |
| Relevance | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
| Host | Mouse |
| Immunogen | His-tagged human XRCC2 |
| Positive Control | HeLa nuclear extracts. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 33 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | XRCC2 7B7/3 does not recognise other paralogs. |
| Research Area | Bacteriology, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 5 entries
Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Europe PMC ID: 11751635
Cartwright et al. 1998. Nucleic Acids Res. 26(13):3084-9. PMID: 9628903.
The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.
Europe PMC ID: 9628903
Add a reference
References: 5 entries
Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Cartwright et al. 1998. Nucleic Acids Res. 26(13):3084-9. PMID: 9628903.
The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.
Add a reference
