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Anti-AP2a [AP2a 8G8/5]


Catalogue Number 151254
Applications ChIP IHC WB
Antigen/Gene or Protein Targets Activating Protein 2 (AP-2) alpha (Human)
Reactivity Human
Relevance AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2ß may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Host Mouse
Immunogen Bacterialy expressed AP-2a/AP-2g fusion protein.
Subclass IgG1
Positive Control Extract from breast cancer cell line ZR75-1
Molecular Weight (kDa) 50
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes AP2a 8G8/5 is specific for the alpha form of AP-2.

Antigen recovery using microwave or pressure cooking required for paraffin embedded tissue.
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling

References: 3 entries

Personal communication

Nordentoft et al. 2011. BMC Cancer. 11:135. PMID: 21489314.

Bennett et al. 2009. PLoS One. 4(9):e6931. PMID: 19742317.

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