Cancer Research Technology
Log in Register
Menu

Anti-DMC1 [2H12/4]

Invented by Dr Stephen West at Francis Crick Institute

Info

Catalogue Number 151239
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets DMC1
Synonyms Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue
Reactivity Bovine, Human and Mouse
Relevance DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.
Host Mouse
Immunogen human DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pelet)
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Unstable after acidic elution.

Does not cross react with hRad51.
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 6 entries

Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.

Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.

Europe PMC ID: 23717213

Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.

Europe PMC ID: 19463812

Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.

The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.

Europe PMC ID: 10562567


Add a reference

References: 6 entries

Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.

Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.

Europe PMC ID: 23717213

Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.

Europe PMC ID: 19463812

Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.

The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.

Europe PMC ID: 10562567


Add a reference

References: 6 entries

Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.

Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.

Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.

The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.

Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.

The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.


Add a reference


This reagent does not have any reviews at the moment.