Anti-Cdc6 [cdc6 9H8/5]
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (9)
- Inventor Info
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| Catalogue Number | 151190 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Cell-division cycle protein 6 (cdc6) |
| Synonyms | Cell Division Cycle 6; Cdc18-Related Protein; CDC6-Related Protein; P62(Cdc6); HsCDC18; CDC18L; HsCDC6; CDC6 Cell Division Cycle 6 Homolog |
| Reactivity | Saccharomyces cerevisiae |
| Relevance | Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae). |
| Host | Mouse |
| Immunogen | cdc6 from S.Cerevisiae. |
| Subclass | IgG1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cell Cycle, Epigenetics & Nuclear Signalling |
References: 9 entries
Evrin et al. 2013. Nucleic Acids Res. 41(5):3162-72. PMID: 23376927.
A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
Europe PMC ID: 23236290
Ikui et al. 2012. PLoS Genet. 8(12):e1003099. PMID: 23236290.
Zhang et al. 2007. Cancer Res. 67(8):3827-34. PMID: 17440097.
Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
Europe PMC ID: 17440097
Perkins et al. 2001. EMBO J. 20(17):4836-45. PMID: 11532947.
Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.
Europe PMC ID: 11532947
Donovan et al. 1997. Proc Natl Acad Sci U S A. 94(11):5611-6. PMID: 9159120.
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.
Europe PMC ID: 9159120
Add a reference
References: 9 entries
Evrin et al. 2013. Nucleic Acids Res. 41(5):3162-72. PMID: 23376927.
A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
Ikui et al. 2012. PLoS Genet. 8(12):e1003099. PMID: 23236290.
Zhang et al. 2007. Cancer Res. 67(8):3827-34. PMID: 17440097.
Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
Perkins et al. 2001. EMBO J. 20(17):4836-45. PMID: 11532947.
Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.
Donovan et al. 1997. Proc Natl Acad Sci U S A. 94(11):5611-6. PMID: 9159120.
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.
Add a reference
