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Anti-HPV16 E1/E4 [TVG 403]


Catalogue Number 151166
Applications ELISA FACS IHC
Antigen/Gene or Protein Targets HPV-16 E1/E4 (early proteins E1 and E4).
Reactivity Human papilloma virus
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer case. E1 and E2 are proteins involved in the regulation of viral DNA replication. TVG 402 and TVG 403 were the first antibodies against HPV16 E1 & E4 and should complement those already available to E7 and L1 for the screening of frozen sections of clinical biopsies. They will be of value in monitoring the progress of HPV infection from benign lesions to invasive cancer.
Host Mouse
Immunogen Antigen for hybridoma production was expressed as a b galactosidase fusion protein using the pEX expression system and was consequently cleaved to release the E1/E4 polypeptide.
Subclass IgG1
Molecular Weight (kDa) 10
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 10% FCS
Notes The epitope recognised by this antibody survived brief fixation in 5% formaldehyde, but not prolonged fixation.
Research Area Cancer, Virology

References: 2 entries

Doorbar et al. 2000. J Virol. 74(21):10081-95. PMID: 11024137.

Doorbar et al. 1992. Virology. 187(1):353-9. PMID: 1371027.

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