Cancer Research Technology
Log in Register
Menu

Anti-Keratin 5/6/18 [LP34]

Invented by Prof Birgit Lane at A*STAR

Info

Catalogue Number 151125
Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets Keratin 5/6/18 (pan-epithelial)
Reactivity Human
Relevance Keratins 5, 6 are members of type II keratins family that are specifically expressed in the inner root sheath of hair follicles. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Keratin 18 is memeber of the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family.

Anti-Keratin 5/6/18 [LP34] shows a broad pattern of reactivity with human epithelial tissues, from simple glandular epithelia to stratified squamous epithelia. Epithelial cells are labelled whether they are ectodermal, mesodermal, or endodermal in origin. However, the recognition of cytokeratin 18 on paraffin sections using this antibody may be variable.
Host Mouse
Immunogen Detergent-insoluble fraction of psoriatic human epidermis
Subclass IgG1
Positive Control Human skin
Molecular Weight (kDa) 10
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cell Signaling & Signal Transduction

References: 10 entries

Barton et al. 2009. Neurosci Lett. 455(1):60-4. PMID: 19429107.

ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.

Europe PMC ID: 19429107

Gardiner et al. 2008. Neuroscientist. 14(3):240-50. PMID: 18270312.

Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.

Europe PMC ID: 18270312

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

Europe PMC ID: 12432088

Braun-Falco et al. 1999. Gene Ther. 6(3):432-41. PMID: 10435093.

IF

Efficient gene transfer into human keratinocytes with recombinant adeno-associated virus vectors.

Europe PMC ID: 10435093

Taylor-Papadimitriou et al., 1987. Keratin expression in the mammary gland. In, The Mammary Gland: Development, Regulation and Function, M.C. Neville and C. Daniel (Eds). Plenum Pub. Corp. 1987, 181-215.

Taylor-Papadimitriou et al., 1983. Cell lineages and interactions in neoplastic expression in the human breast. In, "Understanding Breast Cancer: Clinical and Laboratory Concepts". Eds. Rich, M., Hager, J.C. and Furmanski, P. Marcel Dekker Inc., New Yo


Add a reference

References: 10 entries

Barton et al. 2009. Neurosci Lett. 455(1):60-4. PMID: 19429107.

ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.

Europe PMC ID: 19429107

Gardiner et al. 2008. Neuroscientist. 14(3):240-50. PMID: 18270312.

Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.

Europe PMC ID: 18270312

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

Europe PMC ID: 12432088

Braun-Falco et al. 1999. Gene Ther. 6(3):432-41. PMID: 10435093.

IF

Efficient gene transfer into human keratinocytes with recombinant adeno-associated virus vectors.

Europe PMC ID: 10435093

Taylor-Papadimitriou et al., 1987. Keratin expression in the mammary gland. In, The Mammary Gland: Development, Regulation and Function, M.C. Neville and C. Daniel (Eds). Plenum Pub. Corp. 1987, 181-215.

Taylor-Papadimitriou et al., 1983. Cell lineages and interactions in neoplastic expression in the human breast. In, "Understanding Breast Cancer: Clinical and Laboratory Concepts". Eds. Rich, M., Hager, J.C. and Furmanski, P. Marcel Dekker Inc., New Yo


Add a reference

References: 10 entries

Barton et al. 2009. Neurosci Lett. 455(1):60-4. PMID: 19429107.

ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.

Gardiner et al. 2008. Neuroscientist. 14(3):240-50. PMID: 18270312.

Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

Braun-Falco et al. 1999. Gene Ther. 6(3):432-41. PMID: 10435093.

IF

Efficient gene transfer into human keratinocytes with recombinant adeno-associated virus vectors.

Taylor-Papadimitriou et al., 1987. Keratin expression in the mammary gland. In, The Mammary Gland: Development, Regulation and Function, M.C. Neville and C. Daniel (Eds). Plenum Pub. Corp. 1987, 181-215.

Taylor-Papadimitriou et al., 1983. Cell lineages and interactions in neoplastic expression in the human breast. In, "Understanding Breast Cancer: Clinical and Laboratory Concepts". Eds. Rich, M., Hager, J.C. and Furmanski, P. Marcel Dekker Inc., New Yo


Add a reference


This reagent does not have any reviews at the moment.