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|Applications||ELISA IHC IF WB|
|Antigen/Gene or Protein Targets||Keratin 5/6/18 (pan-epithelial)|
Keratins 5, 6 are members of type II keratins family that are specifically expressed in the inner root sheath of hair follicles. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Keratin 18 is memeber of the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family.
Anti-Keratin 5/6/18 [LP34] shows a broad pattern of reactivity with human epithelial tissues, from simple glandular epithelia to stratified squamous epithelia. Epithelial cells are labelled whether they are ectodermal, mesodermal, or endodermal in origin. However, the recognition of cytokeratin 18 on paraffin sections using this antibody may be variable.
|Immunogen||Detergent-insoluble fraction of psoriatic human epidermis|
|Positive Control||Human skin|
|Molecular Weight (kDa)||10|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Research Area||Cell Signaling & Signal Transduction|
References: 6 entries
Barton et al. 2009. Neurosci Lett. 455(1):60-4. PMID: 19429107.
Gardiner et al. 2008. Neuroscientist. 14(3):240-50. PMID: 18270312.
Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.
Braun-Falco et al. 1999. Gene Ther. 6(3):432-41. PMID: 10435093.
Taylor-Papadimitriou et al., 1987. Keratin expression in the mammary gland. In, The Mammary Gland: Development, Regulation and Function, M.C. Neville and C. Daniel (Eds). Plenum Pub. Corp. 1987, 181-215.
Taylor-Papadimitriou et al., 1983. Cell lineages and interactions in neoplastic expression in the human breast. In, "Understanding Breast Cancer: Clinical and Laboratory Concepts". Eds. Rich, M., Hager, J.C. and Furmanski, P. Marcel Dekker Inc., New Yo
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