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Anti-Integrin aM [ICRF44]

Info

Catalogue Number 151052
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Integrin alpha M (CD11b; Mac-1a subunit)
Synonyms Integrin Subunit Alpha M; Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence Receptor 4; Antigen CD11b (P170) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
Reactivity Human and Primate
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M (CD11B) is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1.
Host Mouse
Immunogen Rheumatoid synovial cells and human monocytes.
Subclass IgG1
Positive Control Monocytes or neutrophils
Molecular Weight (kDa) 160
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Adhesion

References: 14 entries

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FACS

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Chen et al. 2016. J Immunol. :. PMID: 26764035.

FACS

Jobe et al. 2015. J Leukoc Biol. :. PMID: 26667473.

Tosh et al. 2015. J Immunol. :. PMID: 26597011.

FACS

Sugimoto et al. 2015. J Immunol. 195(4):1774-81. PMID: 26179903.

FACS

Riise et al. 2015. J Immunol. 195(3):1121-8. PMID: 26085684.

Tarique et al. 2015. Am J Respir Cell Mol Biol. :. PMID: 25870903.

Mohanty et al. 2015. J Infect Dis. 211(7):1174-84. PMID: 25367297.

Hong et al. 2015. Nat Commun. 6:6588. PMID: 25807344.

Thurlow et al. 2010. Infect Immun. 78(11):4936-43. PMID: 20713628.

Stapulionis et al. 2008. J Immunol. 180(6):3946-56. PMID: 18322203.

Malhotra et al. 1986. Eur J Immunol. 16(9):1117-23. PMID: 3530784.


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