Cancer Research Technology
Log in Register
Menu

Info

Catalogue Number 151052
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Integrin alpha M (CD11b; Mac-1a subunit)
Synonyms Integrin Subunit Alpha M; Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence Receptor 4; Antigen CD11b (P170) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
Reactivity Human and Primate
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M (CD11B) is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1.
Host Mouse
Immunogen Rheumatoid synovial cells and human monocytes.
Subclass IgG1
Positive Control Monocytes or neutrophils
Molecular Weight (kDa) 160
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Adhesion

References: 28 entries

Serr et al. 2016. Nat Commun. 7:10991. PMID: 26975663.

FACS

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Europe PMC ID: 26975663

Wong et al. 2016. Sci Rep. 6:21023. PMID: 26876805.

The Role of Physical Stabilization in Whole Blood Preservation.

Europe PMC ID: 26876805

Bock et al. 2016. Pharmacol Res. :. PMID: 26794428.

Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement.

Europe PMC ID: 26794428

Chen et al. 2016. J Immunol. :. PMID: 26764035.

FACS

Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis.

Europe PMC ID: 26764035

Jobe et al. 2015. J Leukoc Biol. :. PMID: 26667473.

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region.

Europe PMC ID: 26667473

Tosh et al. 2015. J Immunol. :. PMID: 26597011.

FACS

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Europe PMC ID: 26597011

Sugimoto et al. 2015. J Immunol. 195(4):1774-81. PMID: 26179903.

FACS

Riise et al. 2015. J Immunol. 195(3):1121-8. PMID: 26085684.

Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.

Europe PMC ID: 26179903

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

Europe PMC ID: 26085684

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

Europe PMC ID: 25870903

Tarique et al. 2015. Am J Respir Cell Mol Biol. :. PMID: 25870903.

Mohanty et al. 2015. J Infect Dis. 211(7):1174-84. PMID: 25367297.

Hong et al. 2015. Nat Commun. 6:6588. PMID: 25807344.

Trained immunity in newborn infants of HBV-infected mothers.

Europe PMC ID: 25807344

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Europe PMC ID: 25367297

Thurlow et al. 2010. Infect Immun. 78(11):4936-43. PMID: 20713628.

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.

Europe PMC ID: 20713628

Stapulionis et al. 2008. J Immunol. 180(6):3946-56. PMID: 18322203.

Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2.

Europe PMC ID: 18322203

Malhotra et al. 1986. Eur J Immunol. 16(9):1117-23. PMID: 3530784.

Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3).

Europe PMC ID: 3530784


Add a reference

References: 28 entries

Serr et al. 2016. Nat Commun. 7:10991. PMID: 26975663.

FACS

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Europe PMC ID: 26975663

Wong et al. 2016. Sci Rep. 6:21023. PMID: 26876805.

The Role of Physical Stabilization in Whole Blood Preservation.

Europe PMC ID: 26876805

Bock et al. 2016. Pharmacol Res. :. PMID: 26794428.

Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement.

Europe PMC ID: 26794428

Chen et al. 2016. J Immunol. :. PMID: 26764035.

FACS

Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis.

Europe PMC ID: 26764035

Jobe et al. 2015. J Leukoc Biol. :. PMID: 26667473.

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region.

Europe PMC ID: 26667473

Tosh et al. 2015. J Immunol. :. PMID: 26597011.

FACS

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Europe PMC ID: 26597011

Sugimoto et al. 2015. J Immunol. 195(4):1774-81. PMID: 26179903.

FACS

Riise et al. 2015. J Immunol. 195(3):1121-8. PMID: 26085684.

Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.

Europe PMC ID: 26179903

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

Europe PMC ID: 26085684

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

Europe PMC ID: 25870903

Tarique et al. 2015. Am J Respir Cell Mol Biol. :. PMID: 25870903.

Mohanty et al. 2015. J Infect Dis. 211(7):1174-84. PMID: 25367297.

Hong et al. 2015. Nat Commun. 6:6588. PMID: 25807344.

Trained immunity in newborn infants of HBV-infected mothers.

Europe PMC ID: 25807344

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Europe PMC ID: 25367297

Thurlow et al. 2010. Infect Immun. 78(11):4936-43. PMID: 20713628.

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.

Europe PMC ID: 20713628

Stapulionis et al. 2008. J Immunol. 180(6):3946-56. PMID: 18322203.

Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2.

Europe PMC ID: 18322203

Malhotra et al. 1986. Eur J Immunol. 16(9):1117-23. PMID: 3530784.

Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3).

Europe PMC ID: 3530784


Add a reference

References: 28 entries

Serr et al. 2016. Nat Commun. 7:10991. PMID: 26975663.

FACS

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Wong et al. 2016. Sci Rep. 6:21023. PMID: 26876805.

The Role of Physical Stabilization in Whole Blood Preservation.

Bock et al. 2016. Pharmacol Res. :. PMID: 26794428.

Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement.

Chen et al. 2016. J Immunol. :. PMID: 26764035.

FACS

Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis.

Jobe et al. 2015. J Leukoc Biol. :. PMID: 26667473.

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region.

Tosh et al. 2015. J Immunol. :. PMID: 26597011.

FACS

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Sugimoto et al. 2015. J Immunol. 195(4):1774-81. PMID: 26179903.

FACS

Riise et al. 2015. J Immunol. 195(3):1121-8. PMID: 26085684.

Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.

Tarique et al. 2015. Am J Respir Cell Mol Biol. :. PMID: 25870903.

Mohanty et al. 2015. J Infect Dis. 211(7):1174-84. PMID: 25367297.

Hong et al. 2015. Nat Commun. 6:6588. PMID: 25807344.

Trained immunity in newborn infants of HBV-infected mothers.

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Thurlow et al. 2010. Infect Immun. 78(11):4936-43. PMID: 20713628.

Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.

Stapulionis et al. 2008. J Immunol. 180(6):3946-56. PMID: 18322203.

Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2.

Malhotra et al. 1986. Eur J Immunol. 16(9):1117-23. PMID: 3530784.

Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3).


Add a reference


This reagent does not have any reviews at the moment.