Please find below our twelfth Ximbio product update. This month’s mailer details monoclonal and recombinant antibodies new to Ximbio developed at CRUK’s Clare Hall laboratories, the University of Oxford, Vertebrate Antibodies and a University from Singapore.
Ximbio introduces 16 new monoclonal antibodies and one new recombinant antibody for licence or purchase.
For licensing and sales enquiries please email: enquiries@ximbio.com
Or call +44 (0)20 3469 6449.
Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed at www.ximbio.com
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Applications: WB
Reactivity: Xenopus laevis Cdc25 (cell division cycle 25) is a dual-specificity phosphatase that controls entry into and progression through various phases of the cell cycle, including mitosis and S phase.
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Applications: WB
Reactivity: Xenopus laevis Cdc25 (cell division cycle 25) is a dual-specificity phosphatase that controls entry into and progression through various phases of the cell cycle, including mitosis and S phase.
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Applications: WB
Reactivity: Human Rat
PMIDs: 18167358, 12713662, 1253864, 11823640, 11803468
Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Belongs to the GOLGA2 family.
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Applications: ELISA FACS IHC IP WB
Reactivity: Human
PMID: 24671186, 22543528, 18354214, 17664159, 11278868, 7505698, 7309278
Recombinantly produced version of the popular anti-Mucin-1 (MUC1) monoclonal. Target is up-regulated in the lactating breast and in carcinomas.
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Applications: ELISA IHC WB
Reactivity: Human WNK1 a serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively.
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Applications: ELISA IHC WB
Reactivity: Human PMID: Submitted
DPPA2 is a SAP domain protein expressed only in pluripotent cells and the developing germ line. DPPA2 binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
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Applications ELISA IHC WB
Reactivity: Human
Anti-BCL2-Associated Athanogene 3 (BAG3) [V65P1E8*D2] is specific for human BAG3. BAG3 is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
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Anti-PAT4 [PAT4/157/D10] & [PAT-4/9/H10]
Applications: ELISA IHC WB
Reactivity: Human PMIDs: 26434594
PAT4 is upregulated in aggressive forms of colorectal cancer and a possible biomarker.
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Applications: ELISA WB IHC
Reactivity: Human CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.
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Applications: IF WB
Reactivity: Human Vamp5 is distributed predominantly in the trans-Golgi network (TGN) and the plasma membrane.
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Applications: IF WB
Reactivity: Human Sorting nexins (SNXs) are 400-700 amino acid hydrophilic proteins that are characterized by the presence of a phospholipid-binding domain, PX domain. They are a diverse group of cellular trafficking proteins. Mammalian SNXs are thought to be important for the sorting of proteins in the endosomal pathway. SNX27 is one of the 34 mammalian SNXs identified. More investigation have to be done to study the cellular function and regulation of SNX27.
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Applications: FACS Fn WB
Reactivity: Virus PMIDs: 25019613, 16378996
Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
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Applications: IP WB
Reactivity: Virus PMID: 16378996
The SΔ3 is a fragment containing residues 168 to 461 of the SARS-CoV) spike (S), structural protein.
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