Cat. #154171
PARG Inhibitor PDD00017272 Small Molecule (Tool Compound)
Cat. #: 154171
Sub-type: Inhibitor
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Contributor
Inventor: Allan Jordan
Institute: Cancer Research UK, Manchester Institute
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: PARG Inhibitor PDD00017272 Small Molecule (Tool Compound)
- Alternate name: Compound 34f, EP323273
- Tool sub type: Inhibitor
- Primary target: Poly(ADP-ribose) Glycohydrolase (PARG)
- Description: Exploiting the DNA damage response for cancer therapy relies on the fact that rapidly proliferating cancer cells have higher incidences of DNA damage, defective DNA repair pathways, genomic instability, or a combination of these facets. 1-3 Poly(ADP-ribosylation) is a post-translational modification that plays an important role in the repair of damaged sections of DNA.4-6 Poly(ADP-ribose) polymerases (PARPs), in particular PARP1, signal the presence of DNA damage and facilitate DNA repair. ...
- Purpose: Inhibitor
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: Poly(ADP-ribose) Glycohydrolase (PARG)
References
- J. Med. Chem.2018612310767-10792