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AP-2γ Antibody (AP2g 6E4/4): sc-53162
- AP-2γ Antibody (AP2g 6E4/4) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against bacterial AP-2α/AP-2α/AP-2γ fusion protein of human origin
- recommended for detection of AP-2γ of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See AP-2γ (6E4/4): sc-12762 for AP-2γ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AP-2γ Antibody (AP2g 6E4/4) for WB and IHC(P) applications. These reagents are now offered in bundles with AP-2γ Antibody (AP2g 6E4/4) (see ordering information below).
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AP-2 transcription factor family members include AP-2α, AP-2β and AP-2γ, which specifically bind to the DNA consensus sequence CCCCAGGC and initiate transcription of selected genes. AP-2, also known as ERF-1, plays a role in regulating estrogen receptor expression. AP-2β, a splice variant of AP-2α, inhibits AP-2 activity. Besides subscribing to the AP-2 complex, AP-2α, AP-2β and AP-2γ proteins compose the OB2-1 transcription factor complex. OB2-1 specifically upregulates expression of the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2α may play an important role in the development of ectodermal-derived tissues. Deleterious mutations involving the AP-2α gene are linked to microphthalmia, corneal clouding and other anterior eye chamber defects. The ubiquitously expressed AP-4 transcription factor specifically binds to the DNA consensus sequence 5′-CAGCTG-3′. AP-4 interacts with promoters for immunoglobulin-κ gene families and simian virus 40. AP-4 may enhance the transcription of the human Huntington′s disease gene. AP-4 is a helix-loop-helix protein that contains two distinctive leucine repeat elements.