CD36 Antibody (SMφ): sc-7309

CD36 Antibody (SMφ) is an IgM κ mouse monoclonal CD36 antibody (also designated CD36 molecule antibody, GPIV antibody, or SCARB3 antibody) that detects the CD36 gene product of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. CD36 Antibody (SMφ) is available as both the non-conjugated anti-CD36 antibody form, as well as multiple conjugated forms of anti-CD36 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. CD36 (collagen type I receptor, thrombospondin receptor, FAT, GP4, GP3B, GPIV, PASIV, SCARB3) is a membrane glycoprotein on platelets, monocytes and umbilical vein endothelial cells. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. CD36 plays a key role in both phagocytosis and lipid recycling, for constant production of mature spermatozoa. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Thrombospondins are widely distributed proteins that influence a variety of adhesive processes and CD36 may have important functions as a cell adhesion molecule.0

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References:

1. Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.  |  Greenwalt, DE., et al. 1992. Blood. 80: 1105-15. PMID: 1381234
2. Macrophage chemotaxis to apoptotic Burkitt′s lymphoma cells in vitro: role of CD14 and CD36.  |  Truman, LA., et al. 2004. Immunobiology. 209: 21-30. PMID: 15481137
3. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.  |  Pohl, J., et al. 2005. Mol Biol Cell. 16: 24-31. PMID: 15496455
4. Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36.  |  Unno, Y., et al. 2004. Biochem Biophys Res Commun. 325: 151-6. PMID: 15522213
5. CD36 is a sensor of diacylglycerides.  |  Hoebe, K., et al. 2005. Nature. 433: 523-7. PMID: 15690042
6. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms.  |  Bastie, CC., et al. 2005. J Biol Chem. 280: 14222-9. PMID: 15691844
7. Collagen induces normal signal transduction in platelets deficient in CD36 (platelet glycoprotein IV).  |  Daniel, JL., et al. 1994. Thromb Haemost. 71: 353-6. PMID: 7518098
8. Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation.  |  Alessio, M., et al. 1996. J Biol Chem. 271: 1770-5. PMID: 8576181
9. Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils.  |  Navazo, MD., et al. 1996. J Biol Chem. 271: 15381-5. PMID: 8663130
10. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells.  |  Dawson, DW., et al. 1997. J Cell Biol. 138: 707-17. PMID: 9245797

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD36 Antibody (SMφ) has 92 citations in a variety of scientific publications.

Primary antibodies like Anti-CD36 Antibody (SMφ) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD36 Antibody (SMφ) Specifications

Alternate Product Name

CD36 molecule

Product Clone Name

SMφ

Classification

Primary Antibody

Clonality

Monoclonal Antibody

Antibody Isotype

IgM kappa light chain

Amino Acids

Epitope Target

CD36

Epitope Species

human

Product Reactivity/Detection

CD36

Species Reactivity/Detection

mouse, rat, human

Additional Mammalian Reactivity

N/A

Additional Non-Mammalian Reactivity

N/A

Applications

WB, IP, IF, IHC(P), FCM

Vialing Information

Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations

92 citations in various scientific publications

Recommended Secondary Detection Reagents

N/A

Available Conjugates/Forms

AC: Agarose, AF488: Alexa Fluor^® 488, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin