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Integrin αL/ITGAL/CD11a Antibody (38): sc-7306
- Integrin αL/ITGAL/CD11a Antibody (38) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against human monocytes
- recommended for detection of Integrin αL of human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Integrin αL/ITGAL/CD11a Antibody (38) for WB and IHC(P) applications. These reagents are now offered in bundles with Integrin αL/ITGAL/CD11a Antibody (38) (see ordering information below).
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Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.