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Integrin αX/ITGAX/CD11c Antibody (3.9): sc-1185

Datasheets
  • Integrin αX/ITGAX/CD11c Antibody (3.9) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
  • raised against human monocytes
  • recommended for detection of Integrin αX of human origin by IP, IF and FCM
  • available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
  • See Integrin αX/ITGAX/CD11c (B-6): sc-46676 for Integrin αX/ITGAX/CD11c antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Integrin αX/ITGAX/CD11c Antibody (3.9) for WB and IHC(P) applications. These reagents are now offered in bundles with Integrin αX/ITGAX/CD11c Antibody (3.9) (see ordering information below).

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Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

How can Integrin αX (3.9): sc-1185 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Professor Griffin
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-1185 PE) or fluoroscein (sc-1185 FITC).
Answered by: Technical Support
Date published: 2017-03-01
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Rated 4 out of 5 by NZ from FITC conjugate works well in Flow FITC conjugate works well in Flow -SCBT QC
Date published: 2013-10-28
Rated 5 out of 5 by SH from Worked well with THP Worked well with THP-1 and HeLa cells in Flow -SCBT Publication Review
Date published: 2009-04-14
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Integrin αX/ITGAX/CD11c Antibody (3.9) is rated 4.5 out of 5 by 2.
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