129-Pik3cbtm1.1Bvan/Cnbc
| Status | Available to order |
| EMMA ID | EM:11633 |
| International strain name | 129-Pik3cbtm1.1Bvan/Cnbc |
| Alternative name | p110beta PI3K-DEL21/22(129) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3cbtm1.1Bvan, |
| Gene/Transgene symbol | Pik3cb |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | Mice in which exons 21 and 22 from Pik3cb/p110beta are constitutively deleted by crossing to a cre-deleter strain - backcrossed onto 129 background. |
| Phenotypic information | Homozygous:Homozygous Pik3cb/p110beta D21-22/D21-22 mice can be obtained but at reduced frequency, it depends on the genetic background.Heterozygous:Mice show reduced phenotypes of homozygous. |
| Breeding history | Backcrossed onto 129Sv for more than 10 generations. |
| References |
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| Homozygous fertile | females only |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous 129S2/SvPasCrl |
Literature references
- The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.;Guillermet-Guibert Julie, Bjorklof Katja, Salpekar Ashreena, Gonella Cristiano, Ramadani Faruk, Bilancio Antonio, Meek Stephen, Smith Andrew J H, Okkenhaug Klaus, Vanhaesebroeck Bart, ;2008;Proceedings of the National Academy of Sciences of the United States of America;105;8292-7; 18544649