B6.Cg-Dmdmdx Tg(DMD*)35del52Lumc/LumcH
| Status | Available to order |
| EMMA ID | EM:12762 |
| International strain name | B6.Cg-Dmdmdx Tg(DMD*)35del52Lumc/LumcH |
| Alternative name | del52 hDMD/mdx mouse |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | human DMD gene carrying a deletion of exon 52 |
| Gene/Transgene symbol | human DMD gene carrying a deletion of exon 52 |
Information from provider
| Provider | Annemieke Aartsma-Rus |
| Provider affiliation | Leiden University Medical Centre |
| Genetic information | Mouse model carrying a mutant human DMD gene (hDMD) integrated in the mouse genome on an mdx background, which carries a mutation in exon 23 of the murine Dmd gene. The mutant hDMD has a deletion of exon 52. |
| Phenotypic information | Homozygous:Develops Duchenne muscular dystrophy.Heterozygous:Develops Duchenne muscular dystrophy. |
| Breeding history | Backcrossed onto C57BL/6J for at least 8 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- A dystrophic Duchenne mouse model for testing human antisense oligonucleotides.;Veltrop Marcel, van Vliet Laura, Hulsker Margriet, Claassens Jill, Brouwers Conny, Breukel Cor, van der Kaa Jos, Linssen Margot M, den Dunnen Johan T, Verbeek Sjef, Aartsma-Rus Annemieke, van Putten Maaike, ;2018;PloS one;13;e0193289; 29466448