B6.Cg-Rock1tm1.1Skmp/SkmpH

Status

Available to order

EMMA IDEM:10372
International strain nameB6.Cg-Rock1tm1.1Skmp/SkmpH
Alternative nameRock1 (C57Bl6J)
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolRock1tm1.1Skmp,
Gene/Transgene symbolRock1

Information from provider

ProviderAfshan McCarthy
Provider affiliationCancer Biology, Institute of Cancer Research
Genetic informationConditionally targeted allele of Rock1.
Phenotypic informationHomozygous:
Floxed homozygous mice are viable and have a normal lifespan.

Heterozygous:
Floxed heterozygous mice are viable and have a normal lifespan.
References
  • Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.;Kümper Sandra, Mardakheh Faraz K, McCarthy Afshan, Yeo Maggie, Stamp Gordon W, Paul Angela, Worboys Jonathan, Sadok Amine, Jørgensen Claus, Guichard Sabrina, Marshall Christopher J, ;2016;eLife;5;e12994; 26765561
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous C57BL/6J
Breeding at archiving centreNo additional breeding was done at the repository

Literature references

  • Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.;Kümper Sandra, Mardakheh Faraz K, McCarthy Afshan, Yeo Maggie, Stamp Gordon W, Paul Angela, Worboys Jonathan, Sadok Amine, Jørgensen Claus, Guichard Sabrina, Marshall Christopher J, ;2016;eLife;5;e12994; 26765561

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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