B6.129-Dll1tm1Mjo/H

Status

Available to order

EMMA IDEM:13522
International strain nameB6.129-Dll1tm1Mjo/H
Alternative nameDll1^tmMjo (Dll1 floxed)
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolDll1tm1Mjo,
Gene/Transgene symbolDll1

Information from provider

ProviderMichael Owen
Provider affiliationFrancis Crick Institute
Genetic informationExons 3 and 4 of the delta like canonical Notch ligand 1 (Dll1) were floxed with and additional loxP site placed downstream to flank the promoter and selection cassette. The selection cassette was later removed by a transfection with cre recombinase expression plasmid.
Phenotypic informationHomozygous:
No phenotype

Heterozygous:
No phenotype
Breeding historyThe background is at least 5 generations crossed to C57BL/6.
References
  • Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.;Hozumi Katsuto, Negishi Naoko, Suzuki Daisuke, Abe Natsumi, Sotomaru Yusuke, Tamaoki Norikazu, Mailhos Carolina, Ish-Horowicz David, Habu Sonoko, Owen Michael J, ;2004;Nature immunology;5;638-44; 15146182
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Literature references

  • Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.;Hozumi Katsuto, Negishi Naoko, Suzuki Daisuke, Abe Natsumi, Sotomaru Yusuke, Tamaoki Norikazu, Mailhos Carolina, Ish-Horowicz David, Habu Sonoko, Owen Michael J, ;2004;Nature immunology;5;638-44; 15146182

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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