B6.129-Dll1tm1Mjo/H
Status | Available to order |
EMMA ID | EM:13522 |
International strain name | B6.129-Dll1tm1Mjo/H |
Alternative name | Dll1^tmMjo (Dll1 floxed) |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Dll1tm1Mjo, |
Gene/Transgene symbol | Dll1 |
Information from provider
Provider | Michael Owen |
Provider affiliation | Francis Crick Institute |
Genetic information | Exons 3 and 4 of the delta like canonical Notch ligand 1 (Dll1) were floxed with and additional loxP site placed downstream to flank the promoter and selection cassette. The selection cassette was later removed by a transfection with cre recombinase expression plasmid. |
Phenotypic information | Homozygous:No phenotypeHeterozygous:No phenotype |
Breeding history | The background is at least 5 generations crossed to C57BL/6. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Alobar holoprosencephaly / Orphanet_93925
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
Literature references
- Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.;Hozumi Katsuto, Negishi Naoko, Suzuki Daisuke, Abe Natsumi, Sotomaru Yusuke, Tamaoki Norikazu, Mailhos Carolina, Ish-Horowicz David, Habu Sonoko, Owen Michael J, ;2004;Nature immunology;5;638-44; 15146182
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