Cat. #160832
4-trifluoromethyl-7-hydrazinyl-2H-chromen-2-one (TFCH) biomolecular fluorophore small molecule (tool compound)
Cat. #: 160832
Sub-type: Fluorescent Probe
Availability: Please enquire for quantities and pricing
Application: Renal tissue imaging. Live cell screening
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Susan Bane ; Kamalika Mukherjee
Institute: Binghamton University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: 4-trifluoromethyl-7-hydrazinyl-2H-chromen-2-one (TFCH) biomolecular fluorophore small molecule (tool compound)
- Alternate name: TFCH
- Tool sub type: Fluorescent Probe
- Description: 4-trifluoromethyl-7-hydrazinyl-2H-chromen-2-one (TFCH) is a novel fluorescent biocompatible probe has been developed to detect oxidative damage in live cells and tissues in as little as 5 minutes. TO accomplish this, TFCH utilizes the irreversible reaction of radicals with biomolecules that result in the covalent addition of carbonyls to biomolecules. This probe has been shown to outperform other commercially available toxicity and reactive oxygen species assays. This probe has been shown to ...
- Application: Renal tissue imaging. Live cell screening
Application Details
- Application: Renal tissue imaging. Live cell screening
References
- A Highly Sensitive Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue
- Mukherjee et al. 2021. ACS Sens. 6(7):2523-2528. PMID: 34214393.
