Cat. #160705
Anti-MR1 [8G3]
Cat. #: 160705
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: MR1
Class: Monoclonal
Application: IP ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jose Villadangos ; Hamish McWilliam
Institute: University of Melbourne
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-MR1 [8G3]
- Alternate name: Major histocompatability complex class I-related gene protein
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 42 kDa
- Strain: C57BL/6
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IP ; WB
- Description: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.
- Immunogen: Peptide sequence from MR1: pwmaenlapdhwer
- Immunogen uniprot id: Q95460
- Isotype: IgG2a kappa
- Myeloma used: Sp2/0
- Recommended controls: The peptide or a lysate of cells expressing MR1
Target Details
- Target: MR1
- Molecular weight: 42 kDa
- Tissue cell line specificity: The peptide or a lysate of cells expressing MR1
- Target background: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.
Applications
- Application: IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- McWilliam et al. 2020. Proc Natl Acad Sci U S A. 117(40):24974-24985. PMID: 32958637.
