#160523

Anti-RA056/11.76.1 [11.76.1]

Cat. #160523

Anti-RA056/11.76.1 [11.76.1]

Cat. #: 160523

Unit size: 100 ug

Availability: 10-12 weeks

Target: Neutrophil Extracellular Trap Antigen

Class: Recombinant

Application: ELISA ; WB

Host: Human

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: Queen Mary University of London

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-RA056/11.76.1 [11.76.1]
  • Alternate name: NET (Neutrophil Extracellular Trap)
  • Clone: 11.76.1
  • Class: Recombinant
  • Conjugation: Unconjugated
  • Host: Human
  • Application: ELISA ; WB
  • Description: Rheumatoid arthritis (RA) is a joint-destructive inflammatory disorder characterized by breach of self-tolerance and production of anti–cit-peptide/protein Abs (ACPA). In the RA synovium, ectopic germinal centers (GCs) support an autoantigen-driven immune response leading to local ACPA+ B cell differentiation (1, 2). Recently, we reported that autoreactive B cells highly mutated within ectopic GCs frequently target cit-histones (cit-H2A/B) contained in neutrophil extracellular trap...
  • Immunogen: TBD
  • Immunogen uniprot id: TBD

Target Details

  • Target: Neutrophil Extracellular Trap Antigen
  • Target background: Rheumatoid arthritis (RA) is a joint-destructive inflammatory disorder characterized by breach of self-tolerance and production of anti–cit-peptide/protein Abs (ACPA). In the RA synovium, ectopic germinal centers (GCs) support an autoantigen-driven immune response leading to local ACPA+ B cell differentiation (1, 2). Recently, we reported that autoreactive B cells highly mutated within ectopic GCs frequently target cit-histones (cit-H2A/B) contained in neutrophil extracellular trap...

Applications

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Corsiero et al. 2020. J Immunol. 204(9):2374-2379. PMID: 32221039.