Late cornified envelope (LCE)3 protein peptide recognition pattern. (a) Affinity data of anti?LCE3 monoclonal antibody against different LCE3 proteins based on enzyme?linked immunosorbent assay (ELISA) analysis; and comparison of the epitope sequences in the LCE3 members. The LCE3B peptide was used for mouse immunization. (b) Immunohistochemical staining of LCE3 proteins in normal human epidermis with the developed anti?LCE3 monoclonal antibody. The picture is representative for the expression in three different skin biopsies. (c) Staining of LCE3 proteins in normal human skin after competition with our anti?LCE3 antibody and LCE peptides. Scale bar = 100 ?m.

Cat. #160445

Anti-pan-late cornified envelope 3, pan-LCE3 [7]

Name: Anti-pan-late cornified envelope 3, pan-LCE3 [7]
SKU: 160445
Price: 300.00 GBP
Availability: InStock

Cat. #: 160445

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Late cornified envelope (LCE) protein 3

Class: Monoclonal

Application: ELISA ; IHC ; IF

Reactivity: Human

Host: Mouse

£300.00

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Contributor

Inventor: Joost Schalkwijk

Institute: Radboud University Medical Center (UMC)

Tool Details

Target Details

Applications

Handling

References

Tool Details

*FOR RESEARCH USE ONLY

Name: Anti-pan-late cornified envelope 3, pan-LCE3 [7]
Alternate name: Late envelope protein 16, Small proline-rich-like epidermal differentiation complex protein 6A, Small proline-rich-like epidermal differentiation complex protein 6B
Tool sub type: Primary antibody
Class: Monoclonal
Purpose: Marker
Conjugation: Unconjugated
Reactivity: Human
Host: Mouse
Application: ELISA ; IHC ; IF
Description: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defence. They have been shown to posses antibacterial (gram positive and negative, aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be a significant risk factor in psoriasis.
Immunogen: Late cornified envelope protein 3B
Myeloma used: Sp2/0

Target Details

Target: Late cornified envelope (LCE) protein 3
Tissue cell line specificity: Mouse
Target background: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defense. They ahve been shown to posses antibacterial (gram positive and negative, aerobic and anearobic speacies) properties. During inflammation they haev been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.

Applications

Application: ELISA ; IHC ; IF

Handling

Format: Liquid
Unit size: 100 ug
Shipping conditions: Shipping at 4° C

References

Niehues et al. 2016. Br J Dermatol. 174(4):795-802. PMID: 26556599.