Cat. #160406
Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Tool Compound)
Cat. #: 160406
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Martin Swarbrick
Institute: Cancer Research Technology AstraZeneca Metabolism Alliance Team
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Tool Compound)
- Alternate name: Synonyms for Phosphatidylinositol-4-phosphate 5-kinase: PIKFYVE, Phosphoinositide Kinase, FYVE Finger Containing Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase Type III, Phosphatidylinositol 3-Phosphate 5-Kinase Type III, Type III PIP Kinase, PIPkin-III, PIP5K3, FYVE Finger-Containing Phosphoinositide Kinase 4, 1-Phosphatidylinositol-3-Phosphate 5-Kinase, Phosphatidylinositol 3-Phosphate 5-Kinase, Zinc Finger FYVE Domain Containing, Epididymis Luminal Protein 37, FYVE Domain Containing 29, KIAA981, ZFYVE29, PIKfyve, HEL37, PIP5K, FAB1, CFD
- Tool sub type: Inhibitor
- Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
- Purpose: Inhibitor
- Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
- Solubility: 15 ľM (Aqueous)
- Additional notes: Relevant Indications: PI3K, PLC, Wnt, Fc-receptor, BAF Negative Control Available: No The compounds are made up to 12mM stock concentration in DMSO. The final concentration of DMSO when treating cells should be less than 1%.
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
- Ic50: PIP5Kι IC50: 0.011 ¾MPIP5Kβ IC50: 0.004 ¾MPIP5Kγ IC50: 0.001 ¾M
References
- Andrews et al. 2014. Eur. J. Cancer. 50(6):91
