#158335

Anti-cyanotoxin (MC-LR) scAb

Cat. #158335

Anti-cyanotoxin (MC-LR) scAb

Cat. #: 158335

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Microcystin-LR

Class: Recombinant

Application: ELISA ; WB

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Caroline Murphy ; Richard O'Kennedy

Institute: Dublin City University

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-cyanotoxin (MC-LR) scAb
  • Alternate name: MC-LR, Anti-Microcystin-LR (R66S) scAb
  • Tool sub type: Primary antibody
  • Class: Recombinant
  • Conjugation: Unconjugated
  • Host: Mouse
  • Application: ELISA ; WB
  • Description: Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A.
  • Immunogen: Microcystin-LR
  • Immunogen uniprot id: TBC

Target Details

  • Target: Microcystin-LR
  • Target background: Microcystins are cyclic heptapeptides implicated in the impairment of liver function in various animals. They have two variable amino acid residues; in the case of the cyanotoxin MC-LR the variable amino acids are Leucine (L) and Arginine (R). Microcystin-LR is the most commonly found cyanotoxin and inhibits protein phosphatase type 1 and type 2A (PP1 and PP2A) activities in the cytoplasm of liver cells, leading to hepatocytic necrosis and haemorrhaging. Chronic exposure to microcystin is a worrying phenomenon as microcystin over an extended period of time can cause cancer through the inhibition of protein phosphatases PP1 and PP2A.

Applications

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: Store at -20° C frozen (best practice). Avoid repeated freeze/thaw cycles. Stable at room temperature in the presence of 20% (v/v) glycerol.
  • Shipping conditions: Shipping at 4° C

References

  • Murphy et al. 2018. J Immunol Methods. 463:127-133. PMID: 30321550.