Cat. #157972
LOX Inhibitor CCT365623 Small Molecule (Tool Compound)
Cat. #: 157972
Sub-type: Inhibitor
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Contributor
Inventor: Leo Leung ; Caroline Springer
Institute: Cancer Research UK, Manchester Institute
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: LOX Inhibitor CCT365623 Small Molecule (Tool Compound)
- Alternate name: LOX, protein-6-lysine oxidase
- Tool sub type: Inhibitor
- Primary target: Lysyl oxidase
- Description: Lysyl oxidase (LOX) and its family members LOX-like (LOXL) are copper-dependent amine oxidases that covalently cross-link collagens and elastin in the tumor extracellular matrix. LOX is secreted as a catalytically inactive 50 kDa pro-protein, which is cleaved to an active 32 kDa enzyme by proteases such as procollagen C-proteinase. LOX and LOXL have variable N-termini, and share a highly conserved C-terminus, where the catalytic domain is located. The catalytic site comprises a copper binding...
- Purpose: Inhibitor
- Additional notes: Patent Application Number WO 2017/141049 A1
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: Lysyl oxidase
- Ic50: 0.90ÎźM
References
- Leung et al. 2019. J Med Chem. 62(12):5863-5884. PMID: 31070916.
