Cat. #157847
CLEFF4 cell line
Cat. #: 157847
Unit size: 1x10^6 cells / vial
Availability: 10-12 weeks
Organism: Human
Tissue: Colon
Model: Mutant
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Andrew Crowe
Institute: Curtin University
Tool Details
*FOR RESEARCH USE ONLY
- Name: CLEFF4 cell line
- Parental cell: Caco-2
- Organism: Human
- Tissue: Colon
- Model: Mutant
- Description: Pharmaceutical drug development requires drug targets to be characterised against efflux transporters. An example is P-glycoprotein (P-gp) which prevents the uptake and trans-cellular transport of hundreds of drug groups. The standard model is to use Caco-2 cells as these can be induced to express high concentrations of P-gp. Said tight junction model can approximate the role of P-gp at the barrier sites in the body including the gastrointestinal tract and also the blood-brain-barrier. There ...
Target Details
- Target: CLEFF4
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
