Cat. #157781
iCKO-Myrf mouse
Cat. #: 157781
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Tamoxifen inducible knockout of Myrf in mature oligodendrocytes
Model: Conditional KO
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ben Emery
Institute: Oregon Health & Science University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: iCKO-Myrf mouse
- Tool sub type: Mouse
- Disease: Tamoxifen inducible knockout of Myrf in mature oligodendrocytes
- Model: Conditional KO
- Conditional: Yes
- Conditional description: inducible conditional myelin regulatory factor knockout mouse
- Description: inducible knockout of Myrf in oligodendrocytes, critical for myelin formation in CNS.
- Genetic background: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%
- Phenotype: iCKO-Myrf
- Strain: C57BL/6
- Breeding information: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Myrf (myelin regulatory factor)
References
- Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.
- Emery et al. 2009. Cell. 138(1):172-85. PMID: 19596243.
- Doerflinger et al. 2003. Genesis. 35(1):63-72. PMID: 12481300.
