Cat. #157699
Anti-Apoptosis (FUS/TLS) Autoantibody [LHC7.15]
Cat. #: 157699
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: hnRNP-P2-TLS, FUS
Class: Monoclonal
Application: IF ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Marko Radic
Institute: The University of Tennessee Health Science Center (UTHSC)
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Apoptosis (FUS/TLS) Autoantibody [LHC7.15]
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 65 kDa
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IF ; WB
- Description: The TAM?/? mouse model (triple homozygous deletions of the Mer, Axl, and Tyro3 receptor tyrosine kinases) has delayed apoptotic cell clearance which causes the production of autoantibodies and autoimmune disease in these mice. The FUS/TLS monoclonal antibody is produced from a spontaneous splenic B cell hybridoma generated from the TAM?/? mouse. FUS/TLS binds DNA, RNA, and ribonucleoprotein in the nucleus and the cytoplasm of live and apoptotic cells. FUS/TLS is involved gene expression, genomic integrity and mRNA processing including pre-mRNA splicing and the export of mRNA to the cytoplasm. Mutations in this gene results in amyotrophic lateral sclerosis type 6 and liposarcoma.
- Immunogen: FUS_HUMAN
- Immunogen uniprot id: FUS_HUMAN
- Recommended controls: IgG2a
Target Details
- Target: hnRNP-P2-TLS, FUS
- Molecular weight: 65 kDa
- Tissue cell line specificity: IgG2a
- Target background: The TAM-/- mouse model (triple homozygous deletions of the Mer, Axl, and Tyro3 receptor tyrosine kinases) has delayed apoptotic cell clearance which causes the production of autoantibodies and autoimmune disease in these mice. The FUS/TLS monoclonal antibody is produced from a spontaneous splenic B cell hybridoma generated from the TAM-/- mouse. FUS/TLS binds DNA, RNA, and ribonucleoprotein in the nucleus and the cytoplasm of live and apoptotic cells. FUS/TLS is involved gene expression, genomic integrity and mRNA processing including pre-mRNA splicing and the export of mRNA to the cytoplasm. Mutations in this gene results in amyotrophic lateral sclerosis type 6 and liposarcoma.
Applications
- Application: IF ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Radic et al. 2006. J Immunol. 176(1):68-74. PMID: 16365397.
