Cat. #156495
Poly(ethylene glycol)poly(lysine) block copolymerubenimex conjugate small molecule (tool compound)
Cat. #: 156495
Sub-type: Inhibitor
Availability: 10-12 weeks
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Masaki Mori ; Hideshi Ishii ; Masamitsu Konno ; Hidetoshi Eguchi ; Naotsgu Haraguchi ; Reishi Toshiyama ; Nobuhiro Nishiyama ; Hiroyasu Takemoto - Osaka University ; Tokyo Institute of Technology ; Tokyo Institute of Technology
Institute: Osaka University ; Tokyo Institute of Technology
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Poly(ethylene glycol)poly(lysine) block copolymerubenimex conjugate small molecule (tool compound)
- Tool sub type: Inhibitor
- Primary target: This conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells
- Description: The molecule exerts stronger inhibitory effect at lower concentrations that Ube alone,suggesting that PLys conjugation effectively increases the antitumor effect in HCC cells, presumably by targeting APN/CD13+cells, and enhances the strength of molecule-to-cell interactions.
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: This conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells
References
- Toshiyama et al. 2019. Oncogene. 38(2):244-260. PMID: 30089817.
