#154832

Anti-Rad51 [Rad51 3C10] rAb

Cat. #154832

Anti-Rad51 [Rad51 3C10] rAb

Cat. #: 154832

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: Rad51

Class: Recombinant

Reactivity: Bovine ; Human ; Pig

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: Absolute Antibody; Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details
Target Details
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Rad51 [Rad51 3C10] rAb
  • Clone: Rad51 3C10
  • Tool sub type: Primary antibody
  • Class: Recombinant
  • Conjugation: Unconjugated
  • Reactivity: Bovine ; Human ; Pig
  • Host: Mouse
  • Description: Recombinant antibody which binds RAD51 recombinase protein, associated with DNA repair pathway. Background and Research Application RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51 catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Mutations in the gene can results in breast cancer, mirror movements 2 and Fanconi anaemia. This is a recombinant version of the anti-RAD51 monoclonal antibody.
  • Immunogen: Full length recombinant human RAD51 protein
  • Immunogen uniprot id: Q06609
  • Isotype: IgG1

Target Details

  • Target: Rad51
  • Target background: Recombinant antibody which binds RAD51 recombinase protein, associated with DNA repair pathway. Background and Research Application RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51 catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Mutations in the gene can results in breast cancer, mirror movements 2 and Fanconi anaemia. This is a recombinant version of the anti-RAD51 monoclonal antibody.

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-Rad51 [Rad51 3C10]

References

  • Barlow et al. 1997. EMBO J. 16(17):5207-15. PMID: 9311981.
  • Distribution of the Rad51 recombinase in human and mouse spermatocytes.
  • Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks.
  • Ivanov et al. 2003. J Cell Sci. 116(Pt 20):4095-106. PMID: 12953071.
  • Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
  • The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.