Cat. #154810
Anti-CD21L [R4/23] rAb
Cat. #: 154810
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
Class: Recombinant
Application: WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Absolute Antibody; University of Oxford
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-CD21L [R4/23] rAb
- Alternate name: Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2
- Clone: R4/23
- Tool sub type: Primary antibody
- Class: Recombinant
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: WB
- Description: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the ÄËĂÂĂÂLongÄËĂÂĂÂ isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
- Immunogen: Cell lysate from a chronic lymphocytic leukemia patient.
- Isotype: IgM
Target Details
- Target: Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
- Target background: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the Long isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
Applications
- Application: WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.
- Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.
- Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.
- Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
- Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.
- Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.
- Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
- Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.