Cat. #154473
Glycated HSA Fluorecein Boronic Acid small molecule (tool compound)
Cat. #: 154473
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Contributor
Inventor: Marta P. Pereira Morais
Institute: University of Bath
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Glycated HSA Fluorecein Boronic Acid small molecule (tool compound)
- Alternate name: AGEs
- Primary target: Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein
- Description: Protein glycation, also known as non-enzymatic glycosylation, has been implicated in various disease states and is therefore an important biomarker for ageing and age-related chronic diseases such as diabetes, cardiovascular diseases, autoimmune diseases, cancer, and Alzheimer's disease. However their analysis is challenging due to the complexity of the protein-carbohydrate adducts. Fluorescent boronic acids like these enable the detection and identification of individual glycated proteins in...
- Additional notes: This small molecule has been used to identify glycated proteins in human serum, insect hemolymph, and mouse brain homogenates.
Handling
- Shipping conditions: Dry Ice
Target Details
- Primary target: Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein
References
- Pereira Morais et al. 2013. Sci Rep. 3:1437. PMID: 23531746.
